The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation

Retinoic acid (RA) is an important intercellular signaling molecule in vertebrate development, with a well-established role in the regulation of hox genes during hindbrain patterning and in neurogenesis. However, the evolutionary origin of the RA signaling pathway remains elusive. To elucidate the e...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Handberg-Thorsager, Mette, Gutierrez-Mazariegos, Juliana, Arold, Stefan T., Kumar Nadendla, Eswar, Bertucci, Paola Y., Germain, Pierre, Tomançak, Pavel, Pierzchalski, Keely, Jones, Jace W., Albalat, Ricard, Kane, Maureen A., Bourguet, William, Laudet, Vincent, Arendt, Detlev, Schubert, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821490/
https://ncbi.nlm.nih.gov/pubmed/29492455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aao1261
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