The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation

Retinoic acid (RA) is an important intercellular signaling molecule in vertebrate development, with a well-established role in the regulation of hox genes during hindbrain patterning and in neurogenesis. However, the evolutionary origin of the RA signaling pathway remains elusive. To elucidate the e...

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Published in:Sci Adv
Main Authors: Handberg-Thorsager, Mette, Gutierrez-Mazariegos, Juliana, Arold, Stefan T., Kumar Nadendla, Eswar, Bertucci, Paola Y., Germain, Pierre, Tomançak, Pavel, Pierzchalski, Keely, Jones, Jace W., Albalat, Ricard, Kane, Maureen A., Bourguet, William, Laudet, Vincent, Arendt, Detlev, Schubert, Michael
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821490/
https://ncbi.nlm.nih.gov/pubmed/29492455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aao1261
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