mTOR pathway activation drives lung cell senescence and emphysema

Chronic obstructive pulmonary disease (COPD) is a highly prevalent and devastating condition for which no curative treatment is available. Exaggerated lung cell senescence may be a major pathogenic factor. Here, we investigated the potential role for mTOR signaling in lung cell senescence and altera...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Houssaini, Amal, Breau, Marielle, Kebe, Kanny, Abid, Shariq, Marcos, Elisabeth, Lipskaia, Larissa, Rideau, Dominique, Parpaleix, Aurelien, Huang, Jin, Amsellem, Valerie, Vienney, Nora, Validire, Pierre, Maitre, Bernard, Attwe, Aya, Lukas, Christina, Vindrieux, David, Boczkowski, Jorge, Derumeaux, Genevieve, Pende, Mario, Bernard, David, Meiners, Silke, Adnot, Serge
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821218/
https://ncbi.nlm.nih.gov/pubmed/29415880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93203
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