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iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction
The role of proinflammation, and specifically TNF-α, on downstream fibrosis and healing after cardiac injury remains unknown. Using iRhom2-deficient mice, which lack myeloid-specific shedding of TNF-α, we reveal increased macrophages (MΦs) that were skewed towards a more proinflammatory (M1) state a...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5821194/ https://ncbi.nlm.nih.gov/pubmed/29415889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98268 |
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