Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction

Crohn’s disease (CD) is a chronic inflammatory disease of the gastrointestinal tract (GIT). Cigarette smoke (CS) exposure and chronic obstructive pulmonary disease (COPD) are risk factors for CD, although the mechanisms involved are poorly understood. We employed a mouse model of CS-induced experime...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Fricker, Michael, Goggins, Bridie J., Mateer, Sean, Jones, Bernadette, Kim, Richard Y., Gellatly, Shaan L., Jarnicki, Andrew G., Powell, Nicholas, Oliver, Brian G., Radford-Smith, Graham, Talley, Nicholas J., Walker, Marjorie M., Keely, Simon, Hansbro, Philip M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821186/
https://ncbi.nlm.nih.gov/pubmed/29415878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94040
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