RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase

Renal fibrosis is a common pathogenic response to injury in chronic kidney disease (CKD). The receptor-interacting protein kinase-3 (RIPK3), a regulator of necroptosis, has been implicated in disease pathogenesis. In mice subjected to unilateral ureteral obstruction–induced (UUO-induced) or adenine...

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Udgivet i:JCI Insight
Main Authors: Imamura, Mitsuru, Moon, Jong-Seok, Chung, Kuei-Pin, Nakahira, Kiichi, Muthukumar, Thangamani, Shingarev, Roman, Ryter, Stefan W., Choi, Augustine M.K., Choi, Mary E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821177/
https://ncbi.nlm.nih.gov/pubmed/29415885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94979
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