TNF receptor–activated factor 2 mediates cardiac protection through noncanonical NF-κB signaling

To elucidate the mechanisms responsible for cytoprotective effects of TNF receptor–activated factor 2 (TRAF2) in the heart, we employed genetic gain- and loss-of-function studies ex vivo and in vivo in mice with cardiac-restricted overexpression of TRAF2 (Myh6-TRAF2(LC)). Crossing Myh6-TRAF2(LC) mic...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Evans, Sarah, Tzeng, Huei-Ping, Veis, Deborah J., Matkovich, Scot, Weinheimer, Carla, Kovacs, Attila, Barger, Philip M., Mann, Douglas L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821173/
https://ncbi.nlm.nih.gov/pubmed/29415884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98278
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