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Out-of-Register Aβ(42) Assemblies as Models for Neurotoxic Oligomers and Fibrils
We propose a variant of the recently found S-shaped Aβ(1-42)-motif that is characterized by out-of-register C-terminal β-strands. We show that chains with this structure can not only form fibrils that are compatible with the NMR signals, but also barrel-shaped oligomers that resemble the ones formed...
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| Pubblicato in: | J Chem Theory Comput |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5821112/ https://ncbi.nlm.nih.gov/pubmed/29357242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jctc.7b01106 |
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