Conserved lipid and small molecule modulation of COQ8 reveals regulation of the ancient kinase-like UbiB family

Human COQ8A (ADCK3) and Saccharomyces cerevisiae Coq8p (collectively COQ8) are UbiB family proteins essential for mitochondrial coenzyme Q (CoQ) biosynthesis. However, the biochemical activity of COQ8 and its direct role in CoQ production remain unclear, in part due to lack of known endogenous regul...

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Publicat a:Cell Chem Biol
Autors principals: Reidenbach, Andrew G., Kemmerer, Zachary A., Aydin, Deniz, Jochem, Adam, McDevitt, Molly T., Hutchins, Paul D., Stark, Jaime L., Stefely, Jonathan A., Reddy, Thiru, Hebert, Alex S., Wilkerson, Emily M., Johnson, Isabel E., Bingman, Craig A., Markley, John L., Coon, Joshua J., Peraro, Matteo Dal, Pagliarini, David J.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819996/
https://ncbi.nlm.nih.gov/pubmed/29198567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.11.001
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