A mouse model study of toxicity and biodistribution of a replication defective adenovirus serotype 5 virus with its genome engineered to contain a decoy hyper binding site to sequester and suppress oncogenic HMGA1 as a new cancer treatment therapy

The HGMA1 architectural transcription factor is highly overexpressed in many human cancers. Because HMGA1 is a hub for regulation of many oncogenes, its overexpression in cancer plays a central role in cancer progression and therefore HMGA1 is gaining increasing attention as a target for development...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Hassan, Faizule, Lossie, Sarah L., Kasik, Ellen P., Channon, Audrey M., Ni, Shuisong, Kennedy, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819794/
https://ncbi.nlm.nih.gov/pubmed/29462157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192882
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