Risk and surrogate benefit for pediatric Phase I trials in oncology: A systematic review with meta-analysis

BACKGROUND: Pediatric Phase I cancer trials are critical for establishing the safety and dosing of anti-cancer treatments in children. Their implementation, however, must contend with the rarity of many pediatric cancers and limits on allowable risk in minors. The aim of this study is to describe th...

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發表在:PLoS Med
Main Authors: Waligora, Marcin, Bala, Malgorzata M., Koperny, Magdalena, Wasylewski, Mateusz T., Strzebonska, Karolina, Jaeschke, Rafał R., Wozniak, Agnieszka, Piasecki, Jan, Sliwka, Agnieszka, Mitus, Jerzy W., Polak, Maciej, Nowis, Dominika, Fergusson, Dean, Kimmelman, Jonathan
格式: Artigo
語言:Inglês
出版: Public Library of Science 2018
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819765/
https://ncbi.nlm.nih.gov/pubmed/29462168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002505
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