Risk and surrogate benefit for pediatric Phase I trials in oncology: A systematic review with meta-analysis

BACKGROUND: Pediatric Phase I cancer trials are critical for establishing the safety and dosing of anti-cancer treatments in children. Their implementation, however, must contend with the rarity of many pediatric cancers and limits on allowable risk in minors. The aim of this study is to describe th...

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Publicado en:PLoS Med
Autores principales: Waligora, Marcin, Bala, Malgorzata M., Koperny, Magdalena, Wasylewski, Mateusz T., Strzebonska, Karolina, Jaeschke, Rafał R., Wozniak, Agnieszka, Piasecki, Jan, Sliwka, Agnieszka, Mitus, Jerzy W., Polak, Maciej, Nowis, Dominika, Fergusson, Dean, Kimmelman, Jonathan
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819765/
https://ncbi.nlm.nih.gov/pubmed/29462168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002505
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