Risk and surrogate benefit for pediatric Phase I trials in oncology: A systematic review with meta-analysis

BACKGROUND: Pediatric Phase I cancer trials are critical for establishing the safety and dosing of anti-cancer treatments in children. Their implementation, however, must contend with the rarity of many pediatric cancers and limits on allowable risk in minors. The aim of this study is to describe th...

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Detalhes bibliográficos
Publicado no:PLoS Med
Main Authors: Waligora, Marcin, Bala, Malgorzata M., Koperny, Magdalena, Wasylewski, Mateusz T., Strzebonska, Karolina, Jaeschke, Rafał R., Wozniak, Agnieszka, Piasecki, Jan, Sliwka, Agnieszka, Mitus, Jerzy W., Polak, Maciej, Nowis, Dominika, Fergusson, Dean, Kimmelman, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819765/
https://ncbi.nlm.nih.gov/pubmed/29462168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002505
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