Risk and surrogate benefit for pediatric Phase I trials in oncology: A systematic review with meta-analysis

BACKGROUND: Pediatric Phase I cancer trials are critical for establishing the safety and dosing of anti-cancer treatments in children. Their implementation, however, must contend with the rarity of many pediatric cancers and limits on allowable risk in minors. The aim of this study is to describe th...

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Pubblicato in:PLoS Med
Autori principali: Waligora, Marcin, Bala, Malgorzata M., Koperny, Magdalena, Wasylewski, Mateusz T., Strzebonska, Karolina, Jaeschke, Rafał R., Wozniak, Agnieszka, Piasecki, Jan, Sliwka, Agnieszka, Mitus, Jerzy W., Polak, Maciej, Nowis, Dominika, Fergusson, Dean, Kimmelman, Jonathan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819765/
https://ncbi.nlm.nih.gov/pubmed/29462168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002505
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