High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing

Myosins adjust their power outputs in response to mechanical loads in an isoform-dependent manner, resulting in their ability to dynamically adapt to a range of motile challenges. Here, we reveal the structural basis for force-sensing based on near-atomic resolution structures of one rigor and two A...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Mentes, Ahmet, Huehn, Andrew, Liu, Xueqi, Zwolak, Adam, Dominguez, Roberto, Shuman, Henry, Ostap, E. Michael, Sindelar, Charles V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2018
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819444/
https://ncbi.nlm.nih.gov/pubmed/29358376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718316115
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