Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis

Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor involved in xenobiotic metabolism. Plexiform neurofibromas (PNFs) can transform into malignant peripheral nerve sheath tumors (MPNSTs) that are resistant to existing therapies. These tumors are primarily composed of Schwann c...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Shackleford, Ghjuvan’Ghjacumu, Sampathkumar, Nirmal Kumar, Hichor, Mehdi, Weill, Laure, Meffre, Delphine, Juricek, Ludmila, Laurendeau, Ingrid, Chevallier, Aline, Ortonne, Nicolas, Larousserie, Frédérique, Herbin, Marc, Bièche, Ivan, Coumoul, Xavier, Beraneck, Mathieu, Baulieu, Etienne-Emile, Charbonnier, Frédéric, Pasmant, Eric, Massaad, Charbel
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819423/
https://ncbi.nlm.nih.gov/pubmed/29351992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715999115
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