Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis

Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor involved in xenobiotic metabolism. Plexiform neurofibromas (PNFs) can transform into malignant peripheral nerve sheath tumors (MPNSTs) that are resistant to existing therapies. These tumors are primarily composed of Schwann c...

詳細記述

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Shackleford, Ghjuvan’Ghjacumu, Sampathkumar, Nirmal Kumar, Hichor, Mehdi, Weill, Laure, Meffre, Delphine, Juricek, Ludmila, Laurendeau, Ingrid, Chevallier, Aline, Ortonne, Nicolas, Larousserie, Frédérique, Herbin, Marc, Bièche, Ivan, Coumoul, Xavier, Beraneck, Mathieu, Baulieu, Etienne-Emile, Charbonnier, Frédéric, Pasmant, Eric, Massaad, Charbel
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2018
主題:
PNAS Plus
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819423/
https://ncbi.nlm.nih.gov/pubmed/29351992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715999115
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