IL-1β enables CNS access to CCR2(hi) monocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells

Molecular interventions that limit pathogenic CNS inflammation are used to treat autoimmune conditions such as multiple sclerosis (MS). Remarkably, IL-1β–knockout mice are highly resistant to experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Here, we show that interfering with...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Paré, Alexandre, Mailhot, Benoit, Lévesque, Sébastien A., Juzwik, Camille, Ignatius Arokia Doss, Prenitha Mercy, Lécuyer, Marc-André, Prat, Alexandre, Rangachari, Manu, Fournier, Alyson, Lacroix, Steve
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819409/
https://ncbi.nlm.nih.gov/pubmed/29358392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714948115
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