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Methyltransferases of gentamicin biosynthesis

Gentamicin C complex from Micromonospora echinospora remains a globally important antibiotic, and there is revived interest in the semisynthesis of analogs that might show improved therapeutic properties. The complex consists of five components differing in their methylation pattern at one or more s...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Li, Sicong, Guo, Junhong, Reva, Anna, Huang, Fanglu, Xiong, Binbin, Liu, Yuanzhen, Deng, Zixin, Leadlay, Peter F., Sun, Yuhui
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819394/
https://ncbi.nlm.nih.gov/pubmed/29358400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711603115
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