Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1

Matrine may be protective against colorectal cancer (CRC), but how it may work is unclear. Thus, we explored the underlying mechanisms of matrine in CRC. Matrine-related proteins and CRC-related genes and therapeutic targets of matrine in CRC were predicted using a network pharmacology approach. Fiv...

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Pubblicato in:J Immunol Res
Autori principali: Fan, Huizhen, Jiang, Chunyan, Zhong, Baoyuan, Sheng, Jianwen, Chen, Ting, Chen, Qingqing, Li, Jingtao, Zhao, Hongchuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818890/
https://ncbi.nlm.nih.gov/pubmed/29546074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/5408324
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