Benchmark dose analyses of multiple genetic toxicity endpoints permit robust, cross-tissue comparisons of MutaMouse responses to orally delivered benzo[a]pyrene

Genetic damage is a key event in tumorigenesis, and chemically induced genotoxic effects are a human health concern. Although genetic toxicity data have historically been interpreted using a qualitative screen-and-bin approach, there is increasing interest in quantitative analysis of genetic toxicit...

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Bibliographische Detailangaben
Veröffentlicht in:Arch Toxicol
Hauptverfasser: Long, Alexandra S., Wills, John W., Krolak, Dorothy, Guo, Matthew, Dertinger, Stephen D., Arlt, Volker M., White, Paul A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2017
Schlagworte:
Genotoxicity and Carcinogenicity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818629/
https://ncbi.nlm.nih.gov/pubmed/29177888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-2099-2
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