The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction

Netrin-1 plays a key role in axon guidance through binding to its receptor, Deleted in Colorectal Cancer (DCC). The initial step of signaling inside the cell after netrin-1/DCC ligation is the binding of DCC cytoplasmic P3 motif to focal adhesion targeting (FAT) domain of focal adhesion kinase (FAK)...

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Xu, Shutong, Liu, Yiqiong, Li, Xiaolong, Liu, Ying, Meijers, Rob, Zhang, Yan, Wang, Jia-huai
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818605/
https://ncbi.nlm.nih.gov/pubmed/29479476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-017-0008-8
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