Filling the Gaps in the Kirromycin Biosynthesis: Deciphering the Role of Genes Involved in Ethylmalonyl-CoA Supply and Tailoring Reactions

Kirromycin is the main product of the soil-dwelling Streptomyces collinus Tü 365. The elucidation of the biosynthetic pathway revealed that the antibiotic is synthesised via a unique combination of trans-/cis-AT type I polyketide synthases and non-ribosomal peptide synthetases (PKS I/NRPS). This was...

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Publicado no:Sci Rep
Main Authors: Robertsen, Helene L., Musiol-Kroll, Ewa M., Ding, Ling, Laiple, Kristina J., Hofeditz, Torben, Wohlleben, Wolfgang, Lee, Sang Yup, Grond, Stephanie, Weber, Tilmann
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818483/
https://ncbi.nlm.nih.gov/pubmed/29459765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21507-6
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