A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase inhibitor (SPIN)

The heme-containing enzyme myeloperoxidase (MPO) is critical for optimal antimicrobial activity of human neutrophils. We recently discovered that the bacterium Staphylococcus aureus expresses a novel immune evasion protein, called SPIN, that binds tightly to MPO, inhibits MPO activity, and contribut...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: de Jong, Nienke W. M., Ploscariu, Nicoleta T., Ramyar, Kasra X., Garcia, Brandon L., Herrera, Alvaro I., Prakash, Om, Katz, Benjamin B., Leidal, Kevin G., Nauseef, William M., van Kessel, Kok P. M., van Strijp, Jos A. G., Geisbrecht, Brian V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818189/
https://ncbi.nlm.nih.gov/pubmed/29306874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000134
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