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Cataract-associated connexin 46 mutation alters its interaction with calmodulin and function of hemichannels
Connexin channels help maintain eye lens homeostasis and transparency. The G143R missense substitution in connexin (Cx) 46 is associated with congenital Coppock cataracts; however, the underlying molecular mechanism is largely unknown. Here, we report that compared with WT Cx46, the G143R substituti...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5818178/ https://ncbi.nlm.nih.gov/pubmed/29298900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001348 |
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