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Schwann cell-specific deletion of the endosomal PI 3-kinase Vps34 leads to delayed radial sorting of axons, arrested myelination, and abnormal ErbB2-ErbB3 tyrosine kinase signaling

The PI 3-kinase Vps34 (Pik3c3) synthesizes phosphatidylinositol 3-phosphate (PI3P), a lipid critical for both endosomal membrane traffic and macroautophagy. Human genetics have implicated PI3P dysregulation, and endosomal trafficking in general, as a recurring cause of demyelinating Charcot-Marie-To...

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Bibliografiska uppgifter
I publikationen:Glia
Huvudupphovsmän: Logan, Anne M., Mammel, Anna E., Robinson, Danielle C., Chin, Andrea L., Condon, Alec F., Robinson, Fred L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818149/
https://ncbi.nlm.nih.gov/pubmed/28617998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23173
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