Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression

NKX2-5 is the most commonly mutated gene associated with human congenital heart defects (CHDs), with a predilection for cardiac pole abnormalities. This homeodomain transcription factor is a central regulator of cardiac development and is expressed in both the first and second heart fields (FHF and...

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Bibliographic Details
Published in:Development
Main Authors: Colombo, Sophie, de Sena-Tomás, Carmen, George, Vanessa, Werdich, Andreas A., Kapur, Sunil, MacRae, Calum A., Targoff, Kimara L.
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818010/
https://ncbi.nlm.nih.gov/pubmed/29361575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.161497
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