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Evaluation of O(6)-Benzylguanine−Potentiated Topical Carmustine for Mycosis Fungoides: A Phase 1-2 Clinical Trial

IMPORTANCE: In a phase 1 trial, single-dose O(6)-benzylguanine with topical carmustine for patients with early stage (stage IA through stage IIA) cutaneous T-cell lymphoma, mycosis fungoides (MF) type, resulted in clinical responses proportional to inhibition of O(6)-alkylguanine–DNA alkyltransferas...

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Detalhes bibliográficos
Publicado no:JAMA Dermatol
Main Authors: Tacastacas, Joselin D., Chan, Derek V., Carlson, Sean, Gerson, Stanton L., Dowlati, Afshin, Fu, Pingfu, Lu, Kurt, Groft, Sarah, Rosenjack, Julie, Honda, Kord, McCormick, Thomas S., Cooper, Kevin D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5817489/
https://ncbi.nlm.nih.gov/pubmed/28199478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamadermatol.2016.5793
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