Therapeutic Effects of FGF23 c-tail Fc in a murine pre-clinical model of X-linked hypophosphatemia via the selective modulation of phosphate reabsorption

Fibroblast growth factor 23 (FGF23) is the causative factor of X-linked hypophosphatemia (XLH), a genetic disorder effecting 1:20,000 that is characterized by excessive phosphate excretion, elevated FGF23 levels and a rickets/osteomalacia phenotype. FGF23 inhibits phosphate reabsorption and suppress...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Johnson, Kristen, Levine, Kymberly, Sergi, Joseph, Chamoun, Jean, Roach, Rachel, Vekich, Jackie, Favis, Mike, Horn, Mark, Cao, Xianjun, Miller, Brian, Snyder, William, Aivazian, Dikran, Reagan, William, Berryman, Edwin, Colangelo, Jennifer, Markiewicz, Victoria, Bagi, Cedo, Brown, Thomas P., Coyle, Anthony, Mohammadi, Moosa, Magram, Jeanne
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816679/
https://ncbi.nlm.nih.gov/pubmed/28600887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3197
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