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Rational engineering of Streptomyces albus J1074 for the overexpression of secondary metabolite gene clusters

BACKGROUND: Genome sequencing revealed that Streptomyces sp. can dedicate up to ~ 10% of their genomes for the biosynthesis of bioactive secondary metabolites. However, the majority of these biosynthetic gene clusters are only weakly expressed or not at all. Indeed, the biosynthesis of natural produ...

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Publicat a:Microb Cell Fact
Autors principals: Kallifidas, Dimitris, Jiang, Guangde, Ding, Yousong, Luesch, Hendrik
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816538/
https://ncbi.nlm.nih.gov/pubmed/29454348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-018-0874-2
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