Immunogenetic novelty confers a selective advantage in host–pathogen coevolution

The major histocompatibility complex (MHC) is crucial to the adaptive immune response of vertebrates and is among the most polymorphic gene families known. Its high diversity is usually attributed to selection imposed by fast-evolving pathogens. Pathogens are thought to evolve to escape recognition...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Phillips, Karl P., Cable, Joanne, Mohammed, Ryan S., Herdegen-Radwan, Magdalena, Raubic, Jarosław, Przesmycka, Karolina J., van Oosterhout, Cock, Radwan, Jacek
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816137/
https://ncbi.nlm.nih.gov/pubmed/29339521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708597115
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