Selective identification of somatic mutations in pancreatic cancer cells through a combination of next-generation sequencing of plasma DNA using molecular barcodes and a bioinformatic variant filter

The accuracy of next-generation sequencing (NGS) for detecting tumor-specific mutations in plasma DNA is hindered by errors introduced during PCR/sequencing, base substitutions caused by DNA damage, and pre-existing mutations in normal cells that are present at a low frequency. Here, we performed NG...

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Publicat a:PLoS One
Autors principals: Kukita, Yoji, Ohkawa, Kazuyoshi, Takada, Ryoji, Uehara, Hiroyuki, Katayama, Kazuhiro, Kato, Kikuya
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815581/
https://ncbi.nlm.nih.gov/pubmed/29451897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192611
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