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Mutation in the Zebrafish cct2 Gene Leads to Abnormalities of Cell Cycle and Cell Death in the Retina: A Model of CCT2-Related Leber Congenital Amaurosis
PURPOSE: The compound heterozygous mutations in the β subunit of chaperonin containing TCP-1 (CCT), encoded by CCT2, lead to the Leber congenital amaurosis (LCA). In this study, a cct2 mutant line of zebrafish was established to investigate the role of CCT2 mutations in LCA in vertebrates. METHODS:...
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| Vydáno v: | Invest Ophthalmol Vis Sci |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Association for Research in Vision and Ophthalmology
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5815422/ https://ncbi.nlm.nih.gov/pubmed/29450543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22919 |
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