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Direct assessment of renal mitochondrial redox state using hyperpolarized (13)C-acetoacetate

PURPOSE: The purpose of this study was to investigate the hyperpolarized ketone body (13)C-acetoacetate (AcAc) and its conversion to (13)C-β-hydroxybutyrate (βOHB) in vivo, catalyzed by β-hydroxybutyrate dehydrogenase (BDH), as a novel direct marker of mitochondrial redox state. METHODS: [1,3-(13)C(...

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Detalhes bibliográficos
Publicado no:Magn Reson Med
Main Authors: von Morze, Cornelius, Ohliger, Michael A., Marco-Rius, Irene, Wilson, David M., Flavell, Robert R., Pearce, David, Vigneron, Daniel B., Kurhanewicz, John, Wang, Zhen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815327/
https://ncbi.nlm.nih.gov/pubmed/29314217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.27054
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