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Direct assessment of renal mitochondrial redox state using hyperpolarized (13)C-acetoacetate
PURPOSE: The purpose of this study was to investigate the hyperpolarized ketone body (13)C-acetoacetate (AcAc) and its conversion to (13)C-β-hydroxybutyrate (βOHB) in vivo, catalyzed by β-hydroxybutyrate dehydrogenase (BDH), as a novel direct marker of mitochondrial redox state. METHODS: [1,3-(13)C(...
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| Gepubliceerd in: | Magn Reson Med |
|---|---|
| Hoofdauteurs: | , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5815327/ https://ncbi.nlm.nih.gov/pubmed/29314217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.27054 |
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