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Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer’s disease

BACKGROUND: Alzheimer’s disease (AD) is a highly prevalent neurodegenerative disorder characterized by pathological hallmarks of beta-amyloid plaque deposits, tau pathology, inflammation, and cognitive decline. Treatment remains a clinical obstacle due to lack of effective therapeutics. Agonists tar...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Casali, Brad T., Reed-Geaghan, Erin G., Landreth, Gary E.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815248/
https://ncbi.nlm.nih.gov/pubmed/29448961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1091-y
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