Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis

Germline mutations in BUB1 and BUB3 have been reported to increase the risk of developing colorectal cancer (CRC) at young age, in presence of variegated aneuploidy and reminiscent dysmorphic traits of mosaic variegated aneuploidy syndrome. We performed a mutational analysis of BUB1 and BUB3 in 456...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Mur, Pilar, De Voer, Richarda M., Olivera-Salguero, Rubén, Rodríguez-Perales, Sandra, Pons, Tirso, Setién, Fernando, Aiza, Gemma, Valdés-Mas, Rafael, Bertini, Angelo, Pineda, Marta, Vreede, Lilian, Navarro, Matilde, Iglesias, Silvia, González, Sara, Brunet, Joan, Valencia, Alfonso, Esteller, Manel, Lázaro, Conxi, Kops, Geert J. P. L., Urioste, Miguel, Puente, Xose S., Capellá, Gabriel, Valle, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Letter to the Editor
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815240/
https://ncbi.nlm.nih.gov/pubmed/29448935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-018-0762-8
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