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Phage Display on the Anti‐infective Target 1‐Deoxy‐d‐xylulose‐5‐phosphate Synthase Leads to an Acceptor–Substrate Competitive Peptidic Inhibitor

Enzymes of the 2‐C‐methyl‐d‐erythritol‐4‐phosphate pathway for the biosynthesis of isoprenoid precursors are validated drug targets. By performing phage display on 1‐deoxy‐d‐xylulose‐5‐phosphate synthase (DXS), which catalyzes the first step of this pathway, we discovered several peptide hits and re...

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Dettagli Bibliografici
Pubblicato in:Chembiochem
Autori principali: Marcozzi, Alessio, Masini, Tiziana, Zhu, Di, Pesce, Diego, Illarionov, Boris, Fischer, Markus, Herrmann, Andreas, Hirsch, Anna K. H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814854/
https://ncbi.nlm.nih.gov/pubmed/29119720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201700402
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