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netSmooth: Network-smoothing based imputation for single cell RNA-seq

Single cell RNA-seq (scRNA-seq) experiments suffer from a range of characteristic technical biases, such as dropouts (zero or near zero counts) and high variance. Current analysis methods rely on imputing missing values by various means of local averaging or regression, often amplifying biases inher...

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Detalhes bibliográficos
Publicado no:F1000Res
Main Authors: Ronen, Jonathan, Akalin, Altuna
Formato: Artigo
Idioma:Inglês
Publicado em: F1000 Research Limited 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814748/
https://ncbi.nlm.nih.gov/pubmed/29511531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.13511.3
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