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6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2
Ubiquitin-specific protease 2 (USP2) belongs to the family of deubiquitinases that can rescue protein targets from proteasomal degradation by reversing their ubiquitination. In various cancers, including prostate cancer and ovarian carcinoma, upregulation of USP2 leads to an increase in the levels o...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5814560/ https://ncbi.nlm.nih.gov/pubmed/29449607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21476-w |
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