Genetic and metabolic comparison of orthotopic and heterotopic patient-derived pancreatic-cancer xenografts to the original patient tumors

Tumors from 25 patients with pancreatic cancer were used to establish two patient-derived xenograft (PDX) models: orthotopic PDX (PDOX) and heterotopic (subcutaneous) PDX (PDHX). We compared gene expression by immunohistochemistry, single-nucleotide polymorphism (SNP), DNA methylation, and metabolit...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Jun, Eunsung, Hong, Seung-Mo, Yoo, Hyun Ju, Kim, Moon-Bo, Won, Ji Sun, An, Soyeon, Shim, In Kyong, Chang, Suhwan, Hoffman, Robert M., Kim, Song Cheol
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814265/
https://ncbi.nlm.nih.gov/pubmed/29487698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23567
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