Age-Associated Decline in Thymic B Cell Expression of Aire and Aire-Dependent Self-Antigens

Although autoimmune disorders are a significant source of morbidity and mortality in older individuals, the mechanisms governing age-associated increases in susceptibility remain incompletely understood. Central T cell tolerance is mediated through presentation of self-antigens by cells constituting...

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Pubblicato in:Cell Rep
Autori principali: Cepeda, Sergio, Cantu, Carolina, Orozco, Stephanie, Xiao, Yangming, Brown, Zoe, Semwal, Manpreet K., Venables, Thomas, Anderson, Mark S., Griffith, Ann V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813500/
https://ncbi.nlm.nih.gov/pubmed/29386114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.015
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