Pharmacokinetic-pharmacodynamic correlations in the development of ginger extract as an anticancer agent

Anticancer efficacy of ginger phenolics (GPs) has been demonstrated in various in vitro assays and xenograft mouse models. However, only sub-therapeutic plasma concentrations of GPs were detected in human and mouse pharmacokinetic (PK) studies. Intriguingly, a significant portion of GPs occurred as...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mukkavilli, Rao, Yang, Chunhua, Tanwar, Reenu Singh, Saxena, Roopali, Gundala, Sushma R., Zhang, Yingyi, Ghareeb, Ahmed, Floyd, Stephan D., Vangala, Subrahmanyam, Kuo, Wei-Wen, Rida, Padmashree C. G., Aneja, Ritu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813242/
https://ncbi.nlm.nih.gov/pubmed/29445099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21125-2
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