Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor

Selective activation of dopamine D1 receptors (D1Rs) has been pursued for 40 years as a therapeutic strategy for neurologic and psychiatric diseases due to the fundamental role of D1Rs in motor function, reward processing, and cognition. All known D1R-selective agonists are catechols, which are rapi...

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Опубликовано в: :Nat Commun
Главные авторы: Gray, David L., Allen, John A., Mente, Scot, O’Connor, Rebecca E., DeMarco, George J., Efremov, Ivan, Tierney, Patrick, Volfson, Dmitri, Davoren, Jennifer, Guilmette, Edward, Salafia, Michelle, Kozak, Rouba, Ehlers, Michael D.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813016/
https://ncbi.nlm.nih.gov/pubmed/29445200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02776-7
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