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Novel ubiquitin-independent nucleolar c-Myc degradation pathway mediated by antizyme 2
The proto-oncogene c-Myc encodes a short-lived protein c-Myc that regulates various cellular processes including cell growth, differentiation and apoptosis. Degradation of c-Myc is catalyzed by the proteasome and requires phosphorylation of Thr-58 for ubiquitination by E3 ubiquitin ligase, Fbxw7/ FB...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5813005/ https://ncbi.nlm.nih.gov/pubmed/29445227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21189-0 |
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