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4S-Hydroxylation of insulin at ProB28 accelerates hexamer dissociation and delays fibrillation
Daily injections of insulin provide lifesaving benefits to millions of diabetics. But currently available prandial insulins are suboptimal: The onset of action is delayed by slow dissociation of the insulin hexamer in the subcutaneous space, and insulin forms amyloid fibrils upon storage in solution...
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| Veröffentlicht in: | J Am Chem Soc |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5812673/ https://ncbi.nlm.nih.gov/pubmed/28598606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b00794 |
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