Isolation of Amyloid Plaques and Neurofibrillary Tangles from Archived Alzheimer’s Disease Tissue Using Laser-Capture Microdissection for Downstream Proteomics

Here, we describe a new method that allows localized proteomics of amyloid plaques and neurofibrillary tangles (NFTs), which are the two pathological hallmarks of Alzheimer’s disease (AD). Amyloid plaques and NFTs are visualized using immunohistochemistry and microdissected from archived, formalin-f...

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Vydáno v:Methods Mol Biol
Hlavní autoři: Drummond, Eleanor, Nayak, Shruti, Pires, Geoffrey, Ueberheide, Beatrix, Wisniewski, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811767/
https://ncbi.nlm.nih.gov/pubmed/29344869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-7558-7_18
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