Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling

Activation of aldosterone/mineralocorticoid receptors (MR) has been implicated in vascular dysfunction of diabetes. Underlying mechanisms are elusive. Therefore, we investigated the role of Rho kinase (ROCK) in aldosterone/MR signaling and vascular dysfunction in a model of diabetes. Diabetic obese...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nguyen Dinh Cat, Aurelie, Callera, Glaucia E., Friederich-Persson, Malou, Sanchez, Ana, Dulak-Lis, Maria Gabriela, Tsiropoulou, Sofia, Montezano, Augusto C., He, Ying, Briones, Ana M., Jaisser, Frederic, Touyz, Rhian M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811612/
https://ncbi.nlm.nih.gov/pubmed/29440699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21087-5
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