Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: The aldosterone-mineralocorticoid receptor-Nox1 axis

AIMS: We questioned whether aldosterone and oxidative stress play a role in vascular damage in severe hypertension and investigated the role of Nox1 in this process. MATERIALS AND METHODS: We studied mesenteric arteries, aortas and vascular smooth muscle cells (VSMC) from WKY and SHRSP rats. Vascula...

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Detalhes bibliográficos
Publicado no:Life Sci
Main Authors: Harvey, Adam P., Montezano, Augusto C., Hood, Katie Y., Lopes, Rheure A., Rios, Francisco, Ceravolo, Graziela, Graham, Delyth, Touyz, Rhian M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446265/
https://ncbi.nlm.nih.gov/pubmed/28478264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2017.05.002
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