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Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi

Protein degradation in lytic compartments is crucial for eukaryotic cells. At the heart of this process, vacuolar sorting receptors (VSRs) bind soluble hydrolases in the secretory pathway and release them into the vacuolar route. Sorting efficiency is suggested to result from receptor recycling. How...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Früholz, Simone, Fäßler, Florian, Kolukisaoglu, Üner, Pimpl, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811495/
https://ncbi.nlm.nih.gov/pubmed/29440677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-02909-6
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