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Tumor architecture and Notch signaling modulate drug response in basal cell carcinoma
Hedgehog (Hh) pathway inhibitors such as vismodegib are highly effective for treating basal cell carcinoma (BCC); however, residual tumor cells frequently persist and regenerate the primary tumor upon drug discontinuation. Here, we show that BCCs are organized into 2 molecularly and functionally dis...
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| Publicado no: | Cancer Cell |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5811398/ https://ncbi.nlm.nih.gov/pubmed/29395868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.12.015 |
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