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Tumor architecture and Notch signaling modulate drug response in basal cell carcinoma

Hedgehog (Hh) pathway inhibitors such as vismodegib are highly effective for treating basal cell carcinoma (BCC); however, residual tumor cells frequently persist and regenerate the primary tumor upon drug discontinuation. Here, we show that BCCs are organized into 2 molecularly and functionally dis...

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Podrobná bibliografie
Vydáno v:Cancer Cell
Hlavní autoři: Eberl, Markus, Mangelberger, Doris, Swanson, Jacob B., Verhaegen, Monique E., Harms, Paul W., Frohm, Marcus L., Dlugosz, Andrzej A., Wong, Sunny Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811398/
https://ncbi.nlm.nih.gov/pubmed/29395868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.12.015
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